Hepatogenous Photosensitization in Cattle – A Case Report

Photosensitization is a biophysical phenomenon Seeno is a two years old male Hereford cross takes place when skin becomes sensitized to certain cattle weighing 463 kg and deworming status are up to wavelengths of sunlight, particularly within the date was presented to University Veterinary Hospital, ultraviolet range of the spectrum, in the presence Faculty of Veterinary Medicine, Universiti Putra within skin cells of specific photodynamic agents [1] Malaysia with the history of dull, depressed, lethargy, or also known as cutaneous disease caused by the pale and icteric mucous membrane, hyperkeratosis activation of different photodynamic agents by long and necrotized skin on the muzzle, necrotized scab at wave ultraviolet light that can result in dermatitis, the tail end, pasty faeces and tick infestation. Upon hyporexia, weight loss, and eventually death of affected physical examination, the temperature, pulse and animals [2-5]. This disease has been described in respiration (TPR) were within normal range. Blood different animal species worldwide [6-8].There are and faecal samples were taken for parasitology four forms of photosensitization: Primary photosensiworkout and the results revealed negative for blood tization (Type 1 photosensitization), aberrant pigment protozoa infection and liver fluke infestation. During synthesis (Type 2 (congenital) photosensitization), hospitalization, 5 blood samples were collected at hepatogenous photosensitization (Type 3 photosensidifferent intervals for the period of two months of tization) and photosensitization of uncertain etiology hospitalization via jugular venipuncture for complete (Type 4 photosensitization) [5]. The primary (Type 1) blood count and serum biochemistry analyses. Seeno manifestation arise due to the ingestion of exogenous was diagnosed to have anemia from the first 3 blood st photodynamic substances contained in plants results where the 1 blood results indicate PCV level of [4,5].Congenital photosensitization (Type 2) is rare in 0.22L/L (normal range 0.24-0.46 L/L) and the anemia th domestic animals, being associated with the aberrant resolved after treatments where during the 4 blood metabolism of porphyrins resulting in the accumusampling the PCV improved to 0.32 L/L. Seeno was lation of photodynamic substances within the blood diagnosed also to have jaundice and hyperbiliruand tissues [4]. Hepatogenous photosensitization binemia where the icteric index from the first blood (Type 3) occurs when the capacity of the liver to sampling was 50 Units (normal < 15 Units), total excrete phylloerythrin, derived from the catabolism of bilirubin was 178.4 μmol/L (normal: 1.7-27.2 μmol/L) alimentary chlorophyll, is impaired [4]. This occurs and conjugated bilirubin 108.2 μmol/L (normal: <10.2 due to any hepatic injury that interferes with the μmol/L) and markedly reduced after treatments where th chlorophyll metabolism leading to accumulation of the icteric index from 5 blood sampling was 15 units, abnormal by-product that should be excreted in the total bilirubin was 15.7 μmol/L and conjugated bile [3].Photosensitization of uncertain etiology (Type bilirubin was 16.1 μmol/L. The y-GT was markedly st 4) has not been possible to ascertain whether the increased where in the 1 blood sample was 407 U/L photosensitization is primary or due to hepatic (normal <25 U/L), the second blood sample was 432 insufficiency [5]. U/L, third blood sample was 549 U/L, the fourth blood Vet. World, 2012, Vol.5(12): 764-766 CLINICAL